Muscle Disease Unit

Muscle Disease Unit


The Muscle Disease Unit at the Manchester Centre for Clinical Neuroscience provides a tertiary muscle service for people in Greater Manchester, and from further afield for some rare conditions. We provide expert multi-disciplinary specialist opinions for adults with confirmed or suspected:

•    Complex and undiagnosed muscle disorders
•    Muscular dystrophies (e.g. Becker dystrophy)
•    Myotonic dystrophy
•    Inflammatory muscle diseases (e.g. Inclusion body myositis)
•    Metabolic myopathies (e.g. McArdle disease, Pompe disease)
•    Spinal muscular atrophy (including delivery of Nusinersen and Risdiplam Managed Access Agreements)
•    Mitochondrial disorders 
•    Patients transitioning from paediatric to adult care

Our Team


MDU logo


The Muscle Disease Unit includes a broad complement of experienced neurologists, specialist nurses, and other colleagues:

•    Neurology (Prof. Mark Roberts, Dr James Lilleker, Dr Tamas Cseh)
•    Nurse Specialist and Care Advisor (Phill Kelly)
•    Neurophysiologists (Dr Ronan Macdonagh, Dr Ranjit Ramdasss)
•    Neuropathologists (Prof. Federico Roncaroli, Dr Daniel DuPlessis)
•    Metabolic medicine (Dr Reena Sharma, Dr Ana Jovanovic, Dr Georgetta Fanea)
•    Rheumatologists (Prof. Hector Chinoy – joint myositis clinic with Dr James Lilleker)
•    Paediatricians at Royal Manchester Children’s Hospital (Lead: Dr Imelda Hughes) and Oswestry (Lead: Prof. Tracey Willis)
•    Respiratory medicine and the Long-Term Ventilation Service at University Hospital of South Manchester (Lead: Dr Andrew Bentley)
•    Geneticists at the Mancehster Centre for Genomic Medicine (Dr Catherine Breen, Dr Audrey Smith)

We have collaborative links with other neuromuscular centres, both in the UK (particularly in Newcastle and London) and internationally. We are active members of the North West Adult and Paediatric Neuromuscular Network.

The Patient Experience

Patients attending the muscle service will receive an expert muscle opinion. In many cases neurophysiology (NCS/EMG) can be performed on the same day if required. Further investigations will be arranged as necessary, and ongoing management of your condition will be discussed. We are increasingly delivering novel treatments to patients with muscle wasting disease, including enzyme replacement and gene therapies.

Useful Links

Muscular Dystrophy UK

The Winsford Neuromuscular Centre

Myositis UK 



We run an active research programme in collaboration with our Clinical Research Facility and with the assistance of a clinical research fellow.

Many of our patients are enrolled in research studies, including trials of new treatments, studies looking at long term outcomes of patients with muscle disease, and genetic research. In collaboration with our Rheumatology colleagues, we have participated in internationally recognised research into inflammatory muscle diseases (e.g. Inclusion Body Myositis). In addition, we have one of the largest cohorts of patients with Pompe disease in the world, many of whom have participated in clinical trials of enzyme replacement and other therapies.

We also host regular educational meetings of the North West Adult and Paediatric Neuromuscular Network.

Referrals / Contact

We generally take referrals from other specialists, especially those in general neurology and rheumatology, via the usual referral pathways. In some instances, direct referral from the GP can be accepted. Special funding arrangements may be required for those living outside of Greater Manchester.

Please contact our secretary and coordinator for further information:

 Nichelle Hookway: 0161 206 2010


Patient information leaflets



Neuromuscular Services: An information guide
Neuromuscular Services: An information guide
pdf document 147 KB