Neurosurgery Research

Neurosurgery Research

Publications from Neurosurgery from Jan 2021



2021 November

Endoscopic transsphenoidal surgery for biochemically and clinically non-functioning adenohypophyseal tumours in the elderly: experience from a single UK centre.

Quah BL, Edwards-Bailey A, Gnanalingham K, Pathmanaban O, Vasilopoulos H, Roncaroli F, Kearney T, Balogun J, Karabatsou K.

Endocrine. 2021 Nov 5. doi: 10.1007/s12020-021-02910-y. Online ahead of print.


2021 September

Neurosurgery activity levels in the United Kingdom and republic of Ireland during the first wave of the covid-19 pandemic - a retrospective cross-sectional cohort study.

Richardson GE, Islim AI, Albanese E, Ahmed A, Aly A, Ammar A, Amoo M, Bhatt H, Bodkin P, Coulter I, Corr P, Elmaadawi I, Elserius A, Fountain DM, George KJ, Gillespie CS, Goel A, Grundy PL, Gurusinghe N, Hartley J, Hasan MT, Javadpour M, Kalra N, Mallucci C, Millward CP, Mohamed B, Mohamed S, Mustafa MA, Nannapaneni R, Nolan D, Patel UJ, Piper RJ, Rajaraman C, Raza-Knight S, Rehman K, Rominiyi O, Sage W, Sharouf F, Sinha S, Sitaraman M, Smith S, Solth A, Stokes S, Taweel BA, Tyagi A, Zaben M, Jenkinson MD, Prasad M. Br J Neurosurg. 2021 Sep 2:1-6. doi: 10.1080/02688697.2021.1968341. Epub ahead of print. PMID: 34472417.

Recommencement of anticoagulation/antiplatelet therapy following non-operative management of a Chronic Subdural Hematoma - Is there an optimal time frame?. Savan Shah, K. Joshi George.  Surg Neurol Int 06-Sep-2021;12:456


2021 July

Seizure Outcome after surgery for Insula High Grade Glioma. 

Pepper J, Cuthbert H, Scott T, Ughratdar I, Wykes V, Watts C, D'Urso P, Karabatsou K, Moor CC, Albanese World Neurosurg. 2021 Jul 31:S1878-8750(21)01123-2. doi: 10.1016/j.wneu.2021.07.114. Online ahead of print.World Neurosurg. 2021. PMID: 34343689 

2021 June

A challenging case of sporadic melanocytoma of the jugular foramen.

Donofrio CA, Roncaroli F, Riccio L, Pereira M, O'Sullivan J, Mayers H, Potter GM, Djoukhadar I, Rutherford SA.
Neurochirurgie. 2021 Jun 19:S0028-3770(21)00162-4. doi:10.1016/j.neuchi.2021.06.001. Epub ahead of print. PMID: 34157339.

Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study. COVIDSurg Collaborative; GlobalSurg Collaborative.
Anaesthesia. 2021 Jun;76(6):748-758. doi: 10.1111/anae.15458. Epub 2021 Mar 9. PMID: 33690889; PMCID: PMC8206995.

2021 May

The impact of COVID-19 on neurosurgical head trauma referrals and admission at a tertiary neurosurgical centre.

Sinha S, Toe KKZ, Wood E, George KJ. J Clin Neurosci. 2021 May;87:50-54. doi: 10.1016/j.jocn.2021.02.021. Epub 2021 Mar 2. PMID: 33863533; PMCID: PMC7923951.

Giant posterior mediastinal schwannoma requiring a thoracoabdominal approach for excision.

Bhowmik A, Bisht S, Zayar Toe KK, Joshi George K Surg Neurol Int. 2021 May 25;12:241. doi: 10.25259/SNI_213_2021. PMID: 34221572; PMCID: PMC8247730.

Value of early post-operative growth hormone testing in predicting long-term remission and residual disease after transsphenoidal surgery for Acromegaly.

Wang YY, Waqar M, Abou-Zeid A, Kearney T, Caputo C, Davis J, Trainer P, Higham C, Roncaroli F, Gnanalingham KK.Neuroendocrinology. 2021 May 28. doi: 10.1159/000517476. Online ahead of print.PMID: 34052822

CSF Rhinorrhoea After Endonasal Intervention to the Skull Base (CRANIAL) - Part 1: Multicenter Pilot Study.
CRANIAL Consortium.World Neurosurg. 2021 May;149:e1077-e1089. doi: 10.1016/j.wneu.2020.12.171. Epub 2021 Jan 11.PMID: 33444844 Free PMC article

CSF Rhinorrhea After Endonasal Intervention to the Skull Base (CRANIAL) - Part 2: Impact of COVID-19.
CRANIAL Consortium.World Neurosurg. 2021 May;149:e1090-e1097. doi: 10.1016/j.wneu.2020.12.169. Epub 2021 Jan 11.PMID: 33444833 Free PMC article. 

The LEGATOS technique: A new tissue-validated dynamic contrast-enhanced MRI method for whole-brain, high-spatial resolution parametric mapping.

Li KL, Lewis D, Coope DJ, Roncaroli F, Agushi E, Pathmanaban ON, King AT, Zhao S, Jackson A, Cootes T, Zhu X.
Magn Reson Med. 2021 May 15. doi:10.1002/mrm.28842. Epub ahead of print. PMID: 33991126.

Primary glomus tumour of the pituitary gland: diagnostic challenges of a rare and potentially aggressive neoplasm.

Quah BL, Donofrio CA, La Rosa S, Brouland JP, Cossu G, Djoukhadar I, Mayers H, Shenjere P, Pereira M, Pathmanaban ON, Murtaza MO, Gattamaneni R, Roncaroli F, Karabatsou K.
Virchows Arch. 2021 May;478(5):977-984. doi: 10.1007/s00428-020-02923-4. Epub 2020 Sep 12. PMID: 32918169; PMCID: PMC8099815.

Anakinra in COVID-19: important considerations for clinical trials.

King A, Vail A, O'Leary C, Hannan C, Brough D, Patel H, Galea J, Ogungbenro K, Wright M, Pathmanaban O, Hulme S, Allan S.
Lancet Rheumatol. 2020 Jul;2(7):e379-e381. doi: 10.1016/S2665-9913(20)30160-0. Epub 2020 May 21. PMID: 32835233; PMCID:PMC7241987


2021 April

Quantitative MR-derived biomarkers as predictors of function and histotype in adenohypophyseal tumours.

Lewis D, Roncaroli F, Kearney T, Coope DJ, Gnanalingham K.Neuroendocrinology. 2021 Apr 26. doi: 10.1159/000516823. Online ahead of print.PMID: 33902055 Free article.

Sporadic vestibular schwannoma: a molecular testing summary.

Sadler KV, Bowers NL, Hartley C, Smith PT, Tobi S, Wallace AJ, King A, Lloyd SKW, Rutherford S, Pathmanaban ON, Hammerbeck-Ward C, Freeman S, Stapleton E, Taylor A, Shaw A, Halliday D, Smith MJ, Evans DG.
J Med Genet. 2021 Apr;58(4):227-233. doi: 10.1136/jmedgenet-2020-107022. Epub 2020 Jun 23. PMID: 32576656.

Powered air-purifying respirators: a solution to shortage of FFP3 filtering facepiece respirators in the operating theatre.

Rees PA, Watson S, Corcoran J, Slade DAJ, Pathmanaban O, Bibi A, Carlson GL.
Br J Surg. 2021 Apr 30;108(4):e160-e161. doi: 10.1093/bjs/znab008. PMID: 3778849.


2021 March

Considerations in revising occipitocervical fixation for dysphagia.

Iqbal M, George KJ. Surg Neurol Int. 2021 Mar 30;12:135. doi: 10.25259/SNI_43_2021. PMID: 33880240; PMCID: PMC8053454.

COVIDSurg Collaborative, GlobalSurg Collaborative. 

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study. 
Br J Surg. 2021 Mar 24:znab101. doi: 10.1093/bjs/znab101. Epub ahead of print. PMID: 33761533; PMCID: PMC7995808

Spinal cord compression from hypertrophic nerve roots in chronic inflammatory demyelinating polyradiculoneuropathy

Hasan MT, Patil S, Chauhan V, Gosal D, Ealing J, Du Plessis D, Soh C, George KJ.. Surg Neurol Int. 2021 Mar 24;12:114. doi: 10.25259/SNI_35_2021. PMID: 33880219; PMCID: PMC8053436.

Circumferential intradural meningioma of the thoracic spine: Case report and literature review.

Bisht S, Laurente R, George KJ. Surg Neurol Int. 2021 Mar 24;12:120. doi: 10.25259/SNI_869_2020. PMID: 33880225; PMCID: PMC8053448.


2021 February

The importance of genetic counseling and screening for people with pathogenic SMARCE1 variants: A family study.

Shoakazemi A, Hewitt A, Smith MJ, du Plessis D, Thomas O, Stivaros SM, Deniz K, Hammerbeck-Ward C, Rutherford SA, King AT, Evans DG.
Am J Med Genet A. 2021 Feb;185(2):561-565. doi:10.1002/ajmg.a.61970. Epub 2020 Nov 13. PMID: 33185983
Comment on: SMARCB1 Gene Mutation Predisposes to Earlier Development of Glioblastoma: A Case Report of Familial GBM.

Smith MJ, Pathmanaban ON, Coope DJ, King AT, Evans DG. J Neuropathol Exp Neurol. 2021 Feb 22;80(3):289-290. doi:10.1093/jnen/nlaa105. PMID: 33617649

The spatial phenotype of genotypically distinct meningiomas demonstrate potential implications of the embryology of the meninges.

Fountain DM, Smith MJ, O'Leary C, Pathmanaban ON, Roncaroli F, Bobola N, King AT, Evans DG. Oncogene. 2021 Feb;40(5):875-884. doi: 10.1038/s41388-020-01568-6. Epub 2020 Dec 1. PMID:33262459.

Endoscopic sublabial transmaxillary approach to the inferior orbit: pearls and pitfalls-A comparative anatomical study.

Donofrio CA, Riccio L, Pathmanaban ON, Fioravanti A, Caputy AJ, Mortini P. Neurosurg Rev. 2021 Feb 10. doi: 10.1007/s10143-021-01494-5. Epub ahead of print. PMID: 33564984.


2021 January 

CovidNeuroOnc: A UK multicenter, prospective cohort study of the impact of the COVID-19 pandemic on the neuro-oncology service.

Fountain DM, Piper RJ, Poon MTC, Solomou G, Brennan PM, Chowdhury YA, Colombo F, Elmoslemany T, Ewbank FG, Grundy PL, Hasan MT, Hilling M, Hutchinson PJ, Karabatsou K, Kolias AG, McSorley NJ, Millward CP, Phang I, Plaha P, Price SJ, Rominiyi O, Sage W, Shumon S, Silva IL, Smith SJ, Surash S, Thomson S, Lau JY, Watts C, Jenkinson MD; British Neurosurgical Trainee Research Collaborative (BNTRC). Neurooncol Adv. 2021 Jan 28;3(1):vdab014. doi: 10.1093/noajnl/vdab014. eCollection 2021 Jan-Dec.Neurooncol Adv. 2021. PMID: 34056602 Free PMC article. 

Optical coherence tomography significance in managing complex neurofibromatosis 2-related papilledema: Report of a case.     

Maria Bacci G, Giordano F, Sardi I, Evans G, Pathmanaban O, Fonte C, Trabalzini F, Nappini S, Mura R, Caputo R.
JRSM Open. 2021 Jan 11;12(1):2054270420981454. doi: 10.1177/2054270420981454. PMID: 33489243; PMCID: PMC7804359.

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

COVIDSurg Collaborative
J Clin Oncol. 2021 Jan 1;39(1):66-78. doi: 10.1200/JCO.20.01933. Epub 2020 Oct 6. PMID: 33021869; PMCID: PMC8189635.


2020 December

Awake craniotomy in the COVID-19 era - technical tips and feasibility.

Razak A, Sloan G, Sebastian J, Ehsan S, Karabatsou K.. J Clin Neurosci. 2020 Dec;82(Pt A):49-51. doi: 10.1016/j.jocn.2020.10.048. Epub 2020 Oct 27.J Clin Neurosci. 2020. PMID: 33317738 Free PMC article. 

Disease course of Neurofibromatosis Type 2; a 30-year follow-up study of 353 patients seen at a single institution.

Forde C, King AT, Rutherford SA, Hammerbeck-Ward C, Lloyd SK, Freeman SR, Pathmanaban ON, Stapleton E, Thomas OM, Laitt RD, Stivaros S, Kilday JP, Vassallo G, McBain C, Kerrigan S, Smith MJ, McCabe MG, Harkness EF, Evans DG. Neuro Oncol. 2020 Dec 18:noaa284. doi:10.1093/neuonc/noaa284. Epub ahead of print. PMID: 33336705.


2020 November

Surgical and Radiotherapeutic Management of Malignant Extradural Spinal Cord Compression.

Loblaw A, George KJ, Misra V. Clin Oncol (R Coll Radiol). 2020 Nov;32(11):745-752. doi: 10.1016/j.clon.2020.07.022. Epub 2020 Aug 19. PMID: 32828635.

Delaying surgery for patients with a previous SARS-CoV-2 infection.

COVIDSurg Collaborative.COVIDSurg Collaborative. Br J Surg. 2020 Nov;107(12):e601-e602. doi: 10.1002/bjs.12050. Epub 2020 Sep 25.Br J Surg. 2020. PMID: 32974904 Free PMC article. No abstract available. 

Delaying surgery for patients with a previous SARS-CoV-2 infection.

COVIDSurg Collaborative. Br J Surg. 2020 Nov;107(12):e601-e602. doi: 10.1002/bjs.12050. Epub 2020 Sep 25. PMID: 32974904; PMCID: PMC7537063.

2020 October

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study. 

Glasbey JC, Nepogodiev D, Simoes JFF, Omar O, Li E, Venn ML, Pgdme, Abou Chaar MK, Capizzi V, Chaudhry D, Desai A, Edwards JG, Evans JP, Fiore M, Videria JF, Ford SJ, Ganly I, Griffiths EA, Gujjuri RR, Kolias AG, Kaafarani HMA, Minaya-Bravo A, McKay SC, Mohan HM, Roberts KJ, San Miguel-Méndez C, Pockney P, Shaw R, Smart NJ, Stewart GD, Sundar Mrcog S, Vidya R, Bhangu AA; COVIDSurg Collaborative.Glasbey JC, et al. J Clin Oncol. 2021 Jan 1;39(1):66-78. doi: 10.1200/JCO.20.01933. Epub 2020 Oct 6.J Clin Oncol. 2021. PMID: 33021869 

Pre- and postoperative need for pituitary hormone replacement in non-adenomatous sellar and parasellar lesions: importance of the sellar encroachment score.

Waqar M, Rampersad S, Bennett D, Kearney T, Gnanalingham KK.Acta Neurochir (Wien). 2020 Oct;162(10):2371-2379. doi: 10.1007/s00701-020-04440-4. Epub 2020 Jun 6.PMID: 32506330 Free PMC article.

Spinal cord herniation following multilevel anterior cervical discectomy and fusion .Sinha S, George KJ. Surg Neurol Int. 2020 Oct 8;11:327. doi: 10.25259/SNI_508_2020.


2020 September

Actinomycin D downregulates Sox2 and improves survival in preclinical models of recurrent glioblastoma.

Taylor JT, Ellison S, Pandele A, Wood S, Nathan E, Forte G, Parker H, Zindy E, Elvin M, Dickson A, Williams KJ, Karabatsou K, McCabe M, McBain C, Bigger BW... Neuro Oncol. 2020 Sep 29;22(9):1289-1301. doi: 10.1093/neuonc/noaa051.Neuro Oncol. 2020. PMID: 32227096 Free PMC article. 

Colorectal carcinoma to pituitary tumour: tumour to tumour metastasis.

Donofrio CA, Pizzimenti C, Djoukhadar I, Kearney T, Gnanalingham K, Roncaroli F.Br J Neurosurg. 2020 Sep 21:1-4. doi: 10.1080/02688697.2020.1823937. Online ahead of print.PMID: 32955367

CSF rhinorrhoea after endonasal intervention to the anterior skull base (CRANIAL): proposal for a prospective multicentre observational cohort study.

Khan DZ, Bandyopadhyay S, Patel V, Schroeder BE, Cabrilo I, Choi D, Cudlip SA, Donnelly N, Dorward NL, Fountain DM, Grieve J, Halliday J, Kolias AG, Mannion RJ, O'Donnell A, Phillips N, Piper RJ, Ramachandran B, Santarius T, Sayal P, Sharma R, Solomou G, Tysome JR, Marcus HJ; Neurology and Neurosurgery Interest Group (NANSIG), British Neurosurgical Trainee Research Collaborative (BNTRC), and CRANIAL Steering Committee, Alalade AF, Ahmed S, Al-Barazi S, Al-Mahfoudh R, Bahl A, Bennett D, Bhalla R, Bhatt P, Dow G, Giamouriadis A, Gilkes C, Gnanalingham K, Hanna B, Hayhurst C, Hempenstall J, Hossain-Ibrahim K, Hughes M, Javadpour M, Jenkins A, Kamel M, Habibullah Khan M, Lacy P, Maratos E, Martin A, Mathad N, Mendoza N, Mirza S, Muquit S, Nair R, Nicholson C, Paluzzi A, Paraskevopoulos D, Pathmanaban O, Pollock J, Ram B, Robertson I, Ross P, Shaw S, Shoakazemi A, Sinha S, Stapleton S, Statham P, Stew B, Thomas N, Tsermoulas G, Weir P, Williams A.Br J Neurosurg. 2020 Sep 10:1-10. doi: 10.1080/02688697.2020.1795622. Online ahead of print.PMID: 32909855

Value of dynamic clinical and biomarker data for mortality risk prediction in COVID-19: a multicentre retrospective cohort study.     

Berzuini C, Hannan C, King A, Vail A, O'Leary C, Brough D, Galea J, Ogungbenro K, Wright M, Pathmanaban O, Hulme S, Allan S, Bernardinelli L, Patel HC.
BMJ Open. 2020 Sep 23;10(9):e041983. doi: 10.1136/bmjopen-2020-041983. PMID: 32967887; PMCID:PMC7513423.

Foramen magnum osteochondroma causing myelopathy in a patient with hereditary multiple exostoses.

Sinha S, Iyer V, George KJ. Surg Neurol Int. 2020 Sep 18;11:296. doi: 10.25259/SNI_378_2020


2020 August

Primary papillary epithelial tumour of the sella: expanding the spectrum of TTF-1-positive sellar lesions.

Roncaroli F, Chatterjee D, Giannini C, Pereira M, La Rosa S, Brouland JP, Gnanalingham K, Galli C, Fernandes B, Lania A, Radotra B.Neuropathol Appl Neurobiol. 2020 Aug;46(5):493-505. doi: 10.1111/nan.12622. Epub 2020 May 9.PMID: 32311761

Combined neurosurgical and orbital intervention for spheno-orbital meningiomas - the Manchester experience.

Young J, Mdanat F, Dharmasena A, Cannon P, Leatherbarrow B, Hammerbeck-Ward C, Rutherford S, Ataullah S. Orbit. 2020 Aug;39(4):251-257. doi: 10.1080/01676830.2019.1673782. Epub 2019 Oct 28. PMID: 31658848.


2020 July

Clinical and neuroradiological characterisation of spinal lesions in adults with Neurofibromatosis type 1.

Curtis-Lopez CM, Soh C, Ealing J, Gareth Evans D, Burkitt Wright EMM, Vassallo G, Karabatsou K, Joshi George K.   J Clin Neurosci. 2020 Jul;77:98-105. doi: 10.1016/j.jocn.2020.05.014. Epub 2020 May 13.J Clin Neurosci. 2020. PMID: 32417129 


2020 June

Primary epithelial-myoepithelial carcinoma of the pituitary gland.
Lavin V, Callipo F, Donofrio CA, Ellwood-Thompson R, Metcalf R, Djoukhadar I, Higham CE, Kearney T, Colaco R, Gnanalingham K, Roncaroli F.Neuropathology. 2020 Jun;40(3):261-267. doi: 10.1111/neup.12628. Epub 2020 Jan 3.PMID: 31900996


2020 June

A novel gold marker to aid intraoperative localisation during spinal surgery!

Dhahri PA, McCreary R, George KJ.  Br J Neurosurg. 2020 Jun;34(3):305-307. doi: 10.1080/02688697.2020.1738339. 


2020 May

The microenvironment in sporadic and neurofibromatosis type II-related vestibular schwannoma: the same tumor or different? A comparative imaging and neuropathology study.

Lewis D, Donofrio CA, O'Leary C, Li KL, Zhu X, Williams R, Djoukhadar I, Agushi E, Hannan CJ, Stapleton E, Lloyd SK, Freeman SR, Wadeson A, Rutherford SA, Hammerbeck-Ward C, Evans DG, Jackson A, Pathmanaban ON, Roncaroli F, King AT, Coope DJ. J Neurosurg. 2020 May 29:1-11. doi:10.3171/2020.3.JNS193230. Epub ahead of print. PMID: 32470937.


2020 February

The inflammatory microenvironment in vestibular schwannoma.

Hannan CJ, Lewis D, O'Leary C, Donofrio CA, Evans DG, Roncaroli F, Brough D, King AT, Coope D, Pathmanaban ON.
Neurooncol Adv. 2020 Feb 27;2(1):vdaa023. doi:10.1093/noajnl/vdaa023. PMID: 32642684; PMCID: PMC7212860.

2020 Jan

The association of spinal deformity with dural ectasia in neurofibromatosis type 1.

Shah S, George KJ. Br J Neurosurg. 2020 Jan;33(6):620-623. doi: 10.1080/02688697.2019.1673313.

Incidence of mosaicism in 1055 de novo NF2 cases: much higher than previous estimates with high utility of next-generation sequencing.

Evans DG, Hartley CL, Smith PT, King AT, Bowers NL, Tobi S, Wallace AJ, Perry M, Anup R, Lloyd SKW, Rutherford SA, Hammerbeck-Ward C, Pathmanaban ON, Stapleton E, Freeman SR, Kellett M, Halliday D, Parry A, Gair JJ, Axon P, Laitt R, Thomas O, Afridi SK, Obholzer R; English Specialist NF research group, Duff C, Stivaros SM, Vassallo G, Harkness EF, Smith MJ.
Genet Med. 2020 Jan;22(1):53-59. doi:10.1038/s41436-019-0598-7. Epub 2019 Jul 5. PMID: 31273341.

Global Perspectives on Task Shifting and Task Sharing in Neurosurgery. 

Robertson FC, Esene IN, Kolias AG, Khan T, Rosseau G, Gormley WB, Park KB, Broekman MLD; Global Neurosurgery Survey Collaborators.Robertson FC, et al. World Neurosurg X. 2019 Sep 9;6:100060. doi: 10.1016/j.wnsx.2019.100060. eCollection 2020 Apr.World Neurosurg X. 2019. PMID: 32309801 Free PMC article. 

The outcome of patients with surgically treated meningioma in England: 1999-2013. A cancer registry data analysis. 

Brodbelt AR, Barclay ME, Greenberg D, Williams M, Jenkinson MD, Karabatsou K.Br J Neurosurg. 2019 Dec;33(6):641-647. doi: 10.1080/02688697.2019.1661965. Epub 2019 Sep 17.Br J Neurosurg. 2019. PMID: 31526136 Free article.